Replication is a useful technique for distributed database systems and has been implemented in EU data grid and HEP in CERN for handling huge data access. Replica selection in their prototypes still can be enhanced to provide high availability, fault tolerant and low in communication cost. This paper introduces a new replica control protocol, named Diagonal Replication in 2D Mesh (DR2M) for grid environment and compares its performance with the previous protocols. The performance in this paper is data availability for read and write operation, which are compared to the Read-One Write-All (ROWA), Voting (VT), Tree Quorum (TQ), Grid Configuration (GC), Three Dimensional Grid Structure (TDGS), and Diagonal Replication on Grid (DRG). This paper discusses the protocol of replicating data for grid environment, putting the protocol in a logical 2D mesh structure by employing the quorums and voting techniques. The data file is copied in a selected replica from the diagonal sites in each quorum. The selection of a replica depends on the diagonal location of the structured 2D mesh network where the middle replica is selected because it is the shortest path to get a copy of the data from most of the direction in the quorum. The algorithm in this paper also calculates the optimized number of nodes to be grouped in each quorum and how many quorums are needed for the number of nodes, N in a network. DR2M protocol also ensures that the data for read and write operations are consistent, by ensuring the quorum must not have a nonempty intersection quorum. To evaluate the DR2M protocol, we developed a simulation model in Java. Our results prove that our protocol improves the performance of data availability compared to the previous data replication protocol, namely Read-One Write-All (ROWA), Voting (VT), Tree Quorum (TQ), Grid Configuration (GC), Three Dimensional Grid Structure (TDGS) , and Diagonal Replication on Grid (DRG).