A predictive method based on Artificial networks has been developed for the thermophysical properties of binary liquid mixtures at (303.15, 313.15 and 323.15) K. In method 1, a committee ANN was trained using 5 physical properties combined with absolute temperature as its input to predict thermo physical properties of liquid mixtures. Using these data, predicted values were determined for intermediate mole fraction of different systems without conducting experiments. In method 2, a committee ANN was trained using mole fraction and molecular weight as its input to predict the thermo physical properties of liquid mixtures. The five physical properties of five binary mixtures were taken for this study along with their molecular weights . ANN with back-propagation algorithm is proposed, for Multi-pass Turning Operation and developed in MATLAB. Compared to other prediction techniques, the proposed ANN approach is highly accurate and error is