文章基本信息

标题：Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads
本地全文：下载
作者：Yoshifumi Murata ; Youko Kodama ; Takashi Isobe 等
期刊名称：International Journal of Polymer Science
印刷版ISSN：1687-9422
电子版ISSN：1687-9430
出版年度：2009
卷号：2009
DOI：10.1155/2009/729057
出版社：Hindawi Publishing Corporation
摘要：Calcium-induced alginate-phosphate composite gel beads were prepared, and model drug release profiles were investigated in vitro. The formation of calcium phosphate in the alginate gel matrix was observed and did not affect the rheological properties of the hydrogel beads. X-ray diffraction patterns showed that the calcium phosphate does not exist in crystalline form in the matrix. The initial release amount and release rate of a water-soluble drug, diclofenac, from the alginate gel beads could be controlled by modifying the composition of the matrix with calcium phosphate. In contrast, the release profile was not affected by the modification for hydrocortisone, a drug only slightly soluble in water.