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标题：Hypolipidaemic Potentials of Solanum melongena and Solanum gilo on Hypercholesterolemic Rabbits
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作者：A.A. Odetola ; Y.O. Iranloye ; O. Akinloye 等
期刊名称：Pakistan Journal of Nutrition
印刷版ISSN：1680-5194
电子版ISSN：1994-7984
出版年度：2004
卷号：3
期号：3
页码：180-187
DOI：10.3923/pjn.2004.180.187
出版社：Asian Network for Scientific Information
摘要：The fresh, ripe fruits of Solanum melongena and Solanum gilo were investigated for their possible hypolidemic potentials in hypercholesterolemia induced in New Zealand white rabbits by feeding the animals with normal diet supplemented with 1% cholesterol and groundnut oil for 3 weeks. Hypercholesterolemic rabbits were thereafter treated with normal diet supplemented with 10% of each fruit for 6 weeks. Rabbits fed with normal diet and hypercholesterolemic diets through out the experiment were used as negative and positive controls respectively. There was a significant increase in the weight of hypercholesterolemic rabbits, both test (Groups D & E) and control (Groups B and C) (P Solanum melongena and Solanum gilo significantly reduced serum total cholesterol by 65.40 and 52.69% respectively, triglyceride by 47.7 and 27%, LDL cholesterol by 85 and 83% respectively. They also increased significantly serum HDL by 24.7 and 25% respectively leading to increased HDL/LDL cholesterol ratio (3.37 and 3.25 respectively). This trend was also similar with liver lipid levels. Histopathological examination of the liver and aorta paraffin section stained with Haematoxylin & Eosine showed fewer lesions in the hypercholesterolemic rabbits treated with Solanum fruits compared with control hypercholesterolemic rabbits. These observations demonstrated that Solanum melongena and Solanum gilo have strong hypolipedemic effect which combined with improved HDL/LDL ratio is an indication of the possible use of this fruit in the treatment of diseases associated with hyperlipidemia such as ishcaemic heart diseases and arteriosclerosis.