文章基本信息

标题：Strong Inverse Association of Serum Parathormone with Plasma HCO₃ in Female Hemodialysis Patients
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作者：M.D. Hamid Nasri ; M.D Azar Baradaran
期刊名称：Pakistan Journal of Nutrition
印刷版ISSN：1680-5194
电子版ISSN：1994-7984
出版年度：2005
卷号：4
期号：6
页码：409-413
DOI：10.3923/pjn.2005.409.413
出版社：Asian Network for Scientific Information
摘要：Secondary hyperparathyroidism(SHPTH) is a common complication of chronic kidney disease and is characterized by elevated levels of serum parathyroid hormone (PTH) and abnormalities in bone and mineral metabolism. This serious disorder could be aggravated by metabolic acidosis which is a common consequence of advanced chronic renal failure and in maintenance dialysis patients. To investigate factors influencing the intensity of secondary hyperparathyroidism (SHPTH) in patients on chronic maintenance haemodialysis we tested the association of relative acidosis of hemodialysis patients with parathyroid gland activity. This is a cross-sectional study that was conducted on patients undergoing maintenance hemodialysis treatment with acetate basis dialysate and polysulfone membrane. Serum calcium (Ca), phosphorus (P), magnesium (Mg), alkaline phosphatase (ALP) and intact serum PTH (iPTH) and plasma HCO₃ were measured. A significant positive correlation of plasma HCO₃ with duration and dosage of hemodialysis were found. In all patients a significant inverse correlation of logarithm of serum iPTH with plasma HCO₃ was seen while this association was very significant in female hemodialysis patients. A strong inverse association between plasma HCO₃ and serum PTH in female gender may show the more aggressive form of SHPTH in this group.