文章基本信息

标题：Tocotrienols and α-Tocopherol Reduced Acute and Chronic Lung Lipid Peroxidation Induced by Paraquat in Rats
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作者：A.Y. Asmadi ; A. Adam ; W.Z. Wan Ngah 等
期刊名称：Pakistan Journal of Nutrition
印刷版ISSN：1680-5194
电子版ISSN：1994-7984
出版年度：2005
卷号：4
期号：2
页码：97-100
DOI：10.3923/pjn.2005.97.100
出版社：Asian Network for Scientific Information
摘要：The effect of dietary tocotrienols and α-tocopherol acetate supplementation on paraquat-induced lung toxicity was investigated in rats. The administration of a single dose of paraquat (20 mg/kg, i.p.) to rats increased lung malondialdehyde (MDA) levels and produced lung edema. Tocotrienols (150 mg/kg pellet) or α-tocopherol (34 mg/kg pellet) supplementation of two months significantly reduced lung MDA levels in rats exposed to paraquat but lung edema was unaffected. However lower doses of tocotrienols in the diet did not significantly lower lung MDA levels compared with the unsupplemented controls. Our results showed that dietary supplementation of tocotrienols and α-tocopherol provides protection against paraquat toxicity possibly through their antioxidant property.