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标题：Lipodystrophic and Lipo-Peroxidative Effects of Hydrogenated Coconut Oil Diet in Rats
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作者：A.A. Odutuga ; A.A. Amballi
期刊名称：Pakistan Journal of Nutrition
印刷版ISSN：1680-5194
电子版ISSN：1994-7984
出版年度：2007
卷号：6
期号：6
页码：593-596
DOI：10.3923/pjn.2007.593.596
出版社：Asian Network for Scientific Information
摘要：The effects of dietary saturated fat on blood lipid and lipoprotein composition and lipid peroxidation were studied in rats. Male albino rats (Rattus norvegicus) were maintained either on diets with 5% fat supplements made of 5% soyabean oil or 5% coconut oil. Similarly, two other groups were fed diets that were isocaloric with the former but contained 25% fat supplements made of 25% soyabean oil or 25% coconut oil. The concentration of triacylglycerols in the plasma of the high coconut oil fed rats was three to six-times those of the others. The concentration of free cholesterol was much higher in the plasma of the coconut oil-fed rats. There were significant decreases in the plasma level of chylomirons, VLDL and HDL, but a significant increase in the LDL level of the coconut oil-fed rats. In all the tissues studied, the malondialdehyde level increased significantly in the coconut oil fed rats and most prominently in the liver and the kidney, while the reduced glutathione levels decreased significantly in the coconut oil-fed rats. It is considered that ingestion of coconut oil for a considerably long time may affect lipid metabolism and alter the structure and function of the enzymes responsible for converting the essential fatty acid s to prostaglandins or their endoperoxide precursors. The increase in the malondialdehyde level and the decrease in the reduced glutathione level are indications of the lipid peroxidative effect of saturated fat diet, while the reduced HDL and high level of LDL can be major contributory factors to atherogenesis.