摘要:Muscle formation and regeneration are critical factors for athlete endurance performance,and the SOX15 gene is one of the important genes for muscle formation and regeneration. Although there are many studies on the relationship between the SOX15 gene and muscle tissue,there are few studies on the relationship between the SOX15 gene and athlete performance relation are very limited number. This study aimed to analyse the SOX15 T/G (rs4227) polymorphisms of soccer referees,who performed 3000 m and above in the Cooper test,and of the control group. For this purpose,30 male soccer referees,who performed 3000 m and above in the Cooper test,were selected. For the control group,30 male participants without a sportsman license were selected. In addition,in this study,ACE I/D (rs4646994) and HGF C/A (rs5745697) polymorphisms were analysed. The results showed a statistically significant difference in SOX15 T/G (χ2 = 10.24,p = 0.006) between the referees and the control group. The SOX15 T allele showed a significantly higher frequency in soccer referees than in the control group. However,our data did not show statistically significant differences in ACE I/D and HGF C/A. Our results suggested that SOX15 T/G polymorphism could be related to the endurance performance of athletes.