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标题：The Impact of Hyperthyroidism on Selected Serum Proteins and Metal Ions in the Population of Lahore and its Surrounding Areas
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作者：Aisha Munawar
期刊名称：Pakistan Journal of Analytical & Environmental Chemistry
印刷版ISSN：1996-918X
电子版ISSN：2221-5255
出版年度：2019
卷号：20
期号：2
页码：151-160
DOI：10.21743/pjaec/2019.12.19
语种：English
出版社：National Centre of Excellence in Analytical Chemsitry
摘要：Inorganic metal ions and the proteins play an essential role in living systems. Different hormones and cellular messengers regulate the hemostasis of organisms. Calcium,magnesium,iron and zinc are abundantly distributed in human bodies and play vital role in many biochemical processes. Albumin and ferritin are also the most abundant proteins present in our bodies and carrying out important physiological processes. A disease state or a medical condition can perturb the normal levels of metal ions and proteins in living systems. In the present study,we have analyzed the serum concentration of Ca,Mg,Fe,Zn,albumin and ferritin of hyperthyroid patients. This study includes 184 collected samples (52 normal subjects and 132 hyperthyroid patients),with age group ranging between 11 to 75 years. During sample collection,only those patients were included for whom hyperthyroidism was initially diagnosed but not taking any medicines yet. The hyperthyroid state was determined by the correlation of FT3,FT4 and TSH. Serum Fe,Ca and albumin levels were determined by spectrophotometric method,while Zu and Mg by atomic absorption spectroscopy (AAS) and ferritin by radioimmunology assay (RIA). Obtained results demonstrated the significant differences in the studied parameters as compared to the normal subjects. .
关键词：Ferritin;Albumin;Hyperthyroidism;Zinc;Iron;Calcium;Magnesium;TSH