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标题：Sublethal concentrations of dichlorvos and paraquat induce genotoxic and histological effects in the Clarias gariepinus
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作者：Ebenezer I. Oladokun ; Temitope O. Sogbanmu ; Joseph C. Anikwe 等
期刊名称：Environmental Health and Toxicology
电子版ISSN：2233-6567
出版年度：2020
卷号：35
期号：3
页码：1-9
DOI：10.5620/eaht.2020013
语种：English
出版社：Korean Society of Environmental Health and Toxicology
摘要：Non-target aquatic organisms such as fish may be impacted by agricultural activities through the run-off of pesticides from farms into aquatic ecosystems. In this study,the genotoxic (erythrocytic micronuclei) and histological effects of sublethal concentrations (1% and 10% of 96-h median lethal concentration (LC50) values) of two pesticides (dichlorvos and paraquat) were evaluated in Clarias gariepinus (the African Sharptooth Catfish) for 28 days. The 96-h LC50 of dichlorvos and paraquat against fingerlings of C. gariepinus was 730 µg/L and 50 µg/L,respectively. There was a significant dose-dependent increase (p<0.05) in micronuclei in the erythrocytes of exposed C. gariepinus (2.00±0.82 ‰ to 3.25±1.26 ‰ for dichlorvos and 2.25±0.96 ‰ to 4.75±0.96 ‰ for paraquat) compared to control (0.75±0.96 ‰) by day 28. Gill histological alterations such as mild to severe necrosis and blunting of secondary lamellae were observed in C. gariepinus exposed to higher sublethal concentrations of both pesticides. This study showed that non-target aquatic organisms like C. gariepinus may be at risk of adverse biological effects from exposure to pesticides from non-point sources. We recommend environmental monitoring and sensitization on responsible pesticide use to stakeholders. This will forestall potential adverse ecological effects in aquatic ecosystems.
关键词：Erythrocytes;Gills;Aquatic organisms;DNA damage;Pesticides;Catfish