文章基本信息

标题：Fat grafts enriched with adipose-derived stem cells
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作者：Ki Yong Hong
期刊名称：Archives of Craniofacial Surgery
印刷版ISSN：2287-1152
出版年度：2020
卷号：21
期号：4
页码：211-218
DOI：10.7181/acfs.2020.00325
出版社：KoreaMed Synapse
摘要：Autologous fat grafts are widely used in soft-tissue augmentation and reconstruction. To reduce the unpredictability of fat grafts and to improve their long-term survival, cell-assisted lipotransfer (CAL) was introduced. In this alternative method, autologous fat is mixed and grafted with stromal vascular fraction cells or adipose-derived stem/stromal cells (ASCs). In regenerative medicine, ASCs exhibit excellent therapeutic potential and are also simple to harvest. Although the efficacy of CAL has been demonstrated in experimental and clinical research, studies on its safety in terms of oncologic risk have reported inconclusive results. In order to establish CAL as a viable stem cell therapeutic approach, it will be necessary to demonstrate its oncologic safety in basic and clinical studies. Doing so could transform the paradigm of clinical strategy and practice for the treatment of a wide variety of diseases.
关键词：Adipose tissue;Adipose-derived mesenchymal stem cells;Transplants