文章基本信息

标题：Blood-brain barrier dysfunction in ischemic stroke and diabetes: the underlying link, mechanisms and future possible therapeutic targets
本地全文：下载
作者：Piyawadee Wicha ; Srijit Das ; Pasuk Mahakkanukrauh 等
期刊名称：Anatomy & Cell Biology
印刷版ISSN：2093-3665
出版年度：2021
卷号：54
期号：2
页码：165-177
DOI：10.5115/acb.20.290
出版社：Anatomy and Cell Biology
摘要：Ischemic stroke caused by occlusion of cerebral artery is responsible for the majority of stroke that increases the morbidity and mortality worldwide. Diabetes mellitus (DM) is a crucial risk factor for ischemic stroke. Prolonged DM causes various microvascular and macrovascular changes, and blood-brain barrier (BBB) permeability that facilitates inflammatory response following stroke. In the acute phase following stroke, BBB disruption has been considered the initial step that induces neurological deficit and functional disabilities. Stroke outcomes are significantly worse among DM. In this article, we review stroke with diabetes-induce BBB damage, as well as underlying mechanism and possible therapeutic targets for stroke with diabetes.
关键词：Blood-brain barrier;Diabetes mellitus;Hyperglycemia;Inflammation;Ischemic stroke