文章基本信息

标题：Nasal eosinophilia and eosinophil peroxidase in children and adolescents with rhinitis
本地全文：下载
作者：Yeonu Choi ; Haeun Jeon ; Eun Ae Yang 等
期刊名称：Korean Journal of Pediatrics
印刷版ISSN：1738-1061
出版年度：2019
卷号：62
期号：9
页码：353-359
DOI：10.3345/kjp.2019.00318
出版社：The Korean Pediatric Society
摘要：Researchers have shown that eosinophil peroxidase (EPO) is a relatively accurate marker of eosinophilia and eosinophil activity. However, its use as a marker of eosinophilic inflammation in nasal secretions is limited because the diagnostic cutoff values of EPO for use as a one-time test for allergic diseases such as allergic rhinitis have not been established. To identify the correlation between nasal eosinophil count and EPO in children and adolescents with rhinitis. We recruited patients <18 years of age with rhinitis for more than 2 weeks or more than 2 episodes a year whose nasal eosinophil and EPO were measured at a single allergy clinic. The eosinophil percentage was calculated by dividing the eosinophil count by the number of total cells under light microscopy at ×1,000 magnification. EPO and protein were measured from nasal secretions. We retrospectively analyzed the correlation between nasal eosinophils and protein-corrected EPO (EPO/protein) value. Of the 67 patients enrolled, 41 were male (61.2%); the mean age was 8.2±4.0 years. The median nasal eosinophil count was 1 and percentage was 1%. The median protein-corrected EPO value was 12.5 ng/μg (range, 0-31 ng/μg). There was a statistically significant correlation between eosinophil count and percentage (P<0.001). However, the eosinophil percentage and EPO did not correlate. The eosinophil count and EPO had a statistically significant correlation (P =0.01). The EPO cutoff value examined for nasal eosinophil counts of 2, 5, 10, and 20 was 17.57 ng/μg regardless of the reference count. The largest area under the curve value was obtained when the receiver operating characteristic curve was drawn using the eosinophil count of 2. Nasal eosinophil count was significantly associated with protein-corrected EPO.
关键词：Child;Eosinophil;Eosinophil peroxidase;Rhinitis