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标题：The relation between serum levels of Epidermal Growth Factor (EGF) and necrotizing enterocolitis in preterm neonates.
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作者：Heba Mostafa Ahmed ; Nsreen Mostafa Kamel
期刊名称：Korean Journal of Pediatrics
印刷版ISSN：1738-1061
出版年度：2019
卷号：62
期号：9
页码：307-311
DOI：10.3345/kjp.2018.07108
出版社：The Korean Pediatric Society
摘要：Necrotizing enterocolitis (NEC) is one of the most serious complications of prematurity. There are many risk factors can contribute to the development of NEC .Epidermal growth factor (EGF) plays a major role in the intestinal barrier function, increases intestinal enzyme activity, and improves nutrient transport . The aim of study is to assess the role of epidermal growth factor in the development of NEC in preterm neonates. 130 preterm neonates were included in the study and were divided into three groups; group 1 (40 preterms with NEC) group 2( 50 preterms with sepsis) and group 3 ( 40 healthy preterms as normal controls).NEC group was then subdivided into medical NEC and surgical NEC. Serum EGF was measured using ELISA. Serum EGF levels (pg/dl) were significantly lower in NEC group (median (IQR) = 9.6 (2 -14) as compared to sepsis (median (IQR) = 10.1 (8 -14) and control group (median (IQR) = 11.2 (8 -14) (p<.001) with no significant difference between sepsis and control groups and was positively correlated to gestational age (r= .7, p <.001). Binary logistic regression test showed that low EGF levels and gestational age could significantly predict the development of NEC. The ROC curve for EGF showed an optimal cutoff value of 8 pg/mL with 73.3 % sensitivity, 98 % specificity and AUC of 0.92. patients with NEC had significantly lower serum levels of EGF (p<.001) indicating that EGF could be a reliable marker of NEC in preterm neonates.
关键词：Epidermal growth factor; Neonates;Necrotizing enterocolitis