文章基本信息

标题：The effects of folate and iron deficiency followed by supplementation on blood morphology and inflammation biomarkers in rats
本地全文：下载
作者：Anna Radziejewska ; Joanna Suliburska ; Paweł Kołodziejski 等
期刊名称：Acta Scientarum Polonorum - Technologia Alimentaria
印刷版ISSN：1644-0730
电子版ISSN：1898-9594
出版年度：2021
卷号：20
期号：2
页码：213-222
DOI：10.17306/J.AFS.0921
出版社：Agricultural University of Poznan Press
摘要：BACKGROUND :Little is known about the relation between iron and folic acid (FA) supplementation and inflammation. The aim of this study was to evaluate the effects of iron and folate deficiency and supplementation on blood morphology parameters, and to assess the role of iron and folate transporters in inflammation. METHODS :A four-week period of FA and iron deficiency in Wistar rats was followed by randomization into a group fed with a diet deficient in FA and supplemented with Fe (DFE), a group fed a diet deficient in Fe and supplemented with FA (DFOL), a group fed a diet supplemented with Fe and FA (FEFOL), a group fed a diet deficient in Fe and FA (D), and a group fed a control diet (C). The blood Crp concentration and blood count were determined. The expression of SLC11A2, SLC46A1, SLC19A1, and TFR2 proteins was assessed using the western blot method. RESULTS :After ten days on the experimental diets, the rats in the DFOL group had a 21% higher concentration of white blood cells (WBC) than the FEFOL group did (p < 0.05). We did not observe any differences between the groups in terms of C-reactive protein (Crp) concentration. We also did not find any other differences between the groups in other morphological parameters. Analysis of the correlation between blood count parameters and the expression of iron and folate transporters gave conflicting results. CONCLUSIONS :To conclude, iron and folate supplementation may affect WBC concentration in the blood.
关键词：folate;inflammation;iron;supplementation;transporters
其他关键词：iron, folate, supplementation, inflammation, transporters