文章基本信息

标题：Vitamin A status and its determinants in patients with cystic fibrosis [pdf]
本地全文：下载
作者：Ewa Sapiejka ; Patrycja Krzyżanowska ; Dariusz Walkowiak 等
期刊名称：Acta Scientarum Polonorum - Technologia Alimentaria
印刷版ISSN：1644-0730
电子版ISSN：1898-9594
出版年度：2017
卷号：16
期号：3
页码：345-354
DOI：10.17306/J.AFS.2017.0473
出版社：Agricultural University of Poznan Press
摘要：Background. Routine administration of vitamin A, recommended in CF patients, can help to prevent its deficiency. However, high vitamin A supplementation may lead to its excessive level and possible toxicity. Therefore, the aim of the present study was to assess the status of vitamin A and the determinants of its body resources in CF patients. Material and methods. In 196 CF patients aged from 4 months to 47 years, the following parameters were analysed: nutritional status (standardized body weight and height, serum albumin concentration) and clinical expression of disease (lung function − spirometry; biochemical markers of liver function − ALT, AST, GGT; respiratory tract colonization by Pseudomonas aeruginosa; diabetes; cirrhosis, non-cirrhotic liver disease; exocrine pancreatic function − fecal elastase-1 concentration; blood clotting – INR and vitamin A supplementation). Results. Median vitamin A concentration in the study group was 383.0 ng/ml (1st–3rd quartile: 316.5–457.0). Vitamin A deficiency was found in 32 (16.3%) subjects studied. Vitamin A concentrations above the reference range were observed only in 3 (1.5%) CF patients. CF patients with vitamin A deficiency were significantly older and had lower values of FEV1 compared to CF subjects with normal vitamin A status. Moreover, vitamin A deficiency occurred more frequently in CF patients with diabetes, Pseudomonas aeruginosa colonization, worse lung function and in those without vitamin A supplementation. However, in multiple linear regression analyses, none of the independent variables was documented to be important for predicting vitamin A status. Conclusions. Vitamin A body resources in CF patients are mostly normal. Moreover, there are no good determinants of vitamin A status in these patients. Further studies targeted at exploring potential toxicity and deficiencies of vitamin A in CF patients are needed.
其他关键词：retinol, fat-soluble vitamins, pancreatic disease, liver cirrhosis, high-performance liquid chromatography