文章基本信息

标题：Reaction-Diffusion on a Spatial Mathematical Model of Cancer Immunotherapy with Effector Cells and IL-2 Compounds’ Interactions
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作者：Sulasri Suddin ; Fajar Adi-Kusumo ; Lina Aryati 等
期刊名称：International Journal of Differential Equations
印刷版ISSN：1687-9643
电子版ISSN：1687-9651
出版年度：2021
卷号：2021
页码：1-10
DOI：10.1155/2021/5535447
出版社：Hindawi Publishing Corporation
摘要：Immunotherapy is one of the future treatments applicable in most cases of cancer including malignant cancer. Malignant cancer usually prevents some genes, e.g., p53 and pRb, from controlling the activation of the cell division and the cell apoptosis. In this paper, we consider the interactions among the cancer cell population, the effector cell population that is a part of the immune system, and cytokines that can be used to stimulate the effector cells called the IL-2 compounds. These interactions depend on both time and spatial position of the cells in the tissue. Mathematically, the spatial movement of the cells is represented by the diffusion terms. We provide an analytical study for the constant equilibria of the reaction-diffusion system describing the above interactions, which show the initial behaviour of the tissue, and we conduct numerical simulation that shows the dynamics along the tissue that represent the immunotherapy effects. In this case, we also consider the steady-state conditions of the system that show the long-time behaviour of these interactions.