文章基本信息

标题：New Insights into Non-Dietary Treatment in Celiac Disease: Emerging Therapeutic Options
本地全文：下载
作者：Verónica Segura ; Ángela Ruiz-Carnicer ; Carolina Sousa 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：7
页码：2146
DOI：10.3390/nu13072146
出版社：MDPI Publishing
摘要：To date, the only treatment for celiac disease (CD) consists of a strict lifelong gluten-free diet (GFD), which has numerous limitations in patients with CD. For this reason, dietary transgressions are frequent, implying intestinal damage and possible long-term complications. There is an unquestionable need for non-dietary alternatives to avoid damage by involuntary contamination or voluntary dietary transgressions. In recent years, different therapies and treatments for CD have been developed and studied based on the degradation of gluten in the intestinal lumen, regulation of the immune response, modulation of intestinal permeability, and induction of immunological tolerance. In this review, therapeutic lines for CD are evaluated with special emphasis on phase III and II clinical trials, some of which have promising results.
关键词：celiac disease; gluten-free diet; gluten; gliadin; gluten immunogenic peptides; non-dietary therapies celiac disease ; gluten-free diet ; gluten ; gliadin ; gluten immunogenic peptides ; non-dietary therapies