文章基本信息

标题：Infancy and Childhood Obesity Grade Predicts Weight Loss in Adulthood: The ONTIME Study
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作者：Eva Morales ; Nathaly Torres-Castillo ; Marta Garaulet 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：7
页码：2132
DOI：10.3390/nu13072132
出版社：MDPI Publishing
摘要：We examined the relationships between intergenerational obesity, weight and size at birth, and obesity from infancy to adolescence with weight loss in response to a dietary intervention. We studied 4264 participants (3369 women; mean age 41.5 ± 12.9 years) of the ONTIME study. Participants followed a weight-loss treatment based on a Mediterranean diet. Associations between grandparental and parental obesity grade, birth weight and size, and obesity grade in infancy, childhood and adolescence with total weight loss in response to treatment were assessed, using multivariate linear regression models. A lower weight loss (kg) in response to treatment was found among participants who were obese during infancy (beta coefficient −2.13 kg; 95% CI, −3.96, −0.30; p = 0.023). Furthermore, obesity during infancy and also during childhood was associated with a slower weekly rate of weight loss during treatment (p < 0.05). In conclusion, obesity in infancy and in childhood impairs the weight-loss response to dietary treatments in adulthood. Tackling obesity throughout early life may improve the effectiveness of weight-loss interventions in adulthood.
关键词：intergenerational obesity; size at birth; body mass index; weight loss; dietary treatment intergenerational obesity ; size at birth ; body mass index ; weight loss ; dietary treatment