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标题：Intensive, prolonged exercise seemingly causes gut dysbiosis in female endurance runners
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作者：So Morishima ; Wataru Aoi ; Aki Kawamura 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2021
卷号：68
期号：3
页码：253-258
DOI：10.3164/jcbn.20-131
出版社：The Society for Free Radical Research Japan
摘要：Intensive, prolonged exercise is known to induce gastrointestinal disorders such as diarrhea, with gut dysbiosis suggested as being one of the causatives. In the present study, we wanted to investigate the relationship between intensive exercise and the gut microbiota status. To that end, the microbiota, the moisture content and the bacterial metabolites (e.g., organic acids) of female endurance runners ( n = 15) and those of non-athletic but healthy, age-matching female controls ( n = 14) were compared. The analysis of the gut microbiota analysis showed that, unlike control subjects, female endurance runners had distinct microbiotas, with some bacteria found in higher abundances likely being involved in gut inflammation. The concentration of succinate, a gut bacterial metabolite regarded as undesirable when accumulated in the lumen, was significantly ( p <0.05) higher in the female endurance runners. Faecalibacterium , that was significantly ( p <0.05) abundant in female endurance runners, can produce succinate in certain environments and hence may contribute to succinate accumulation, at least partly. The present work suggested that the gut microbiotas of female endurance runners are seemingly dysbiotic when compared with those of control subjects. Further investigation of the mechanism by which intensive, prolonged exercise affects the gut microbiota is recommended.
关键词：exercise-induced gastrointestinal disorders;gut microbiota;organic acids;putrefactive metabolites;female endurance runner