文章基本信息

标题：EPIGENETICS AND ITS IMPLICATIONS FOR PSYCHOLOGY
本地全文：下载
作者：Héctor González-Pardo ; Marino Pérez Álvarez
期刊名称：Psicothema
印刷版ISSN：0214-9915
电子版ISSN：1886-144X
出版年度：2013
卷号：25
期号：1
页码：3-12
DOI：10.7334/psicothema2012.327
出版社：Cologio Oficial de Psicólogos del Principado
摘要：Background: Epigenetics is changing the widely accepted linear conception of genome function by explaining how environmental and psychological factors regulate the activity of our genome without involving changes in the DNA sequence. Research has identified epigenetic mechanisms mediating between environmental and psychological factors that contribute to normal and abnormal behavioral development. Method: the emerging field of epigenetics as related to psychology is reviewed. Results: the relationship between genes and behavior is reconsidered in terms of epigenetic mechanisms acting after birth and not only prenatally, as traditionally held. Behavioral epigenetics shows that our behavior could have long-term effects on the regulation of the genome function. In addition, epigenetic mechanisms would be related to psychopathology, as in the case of schizophrenia. In the latter case, it would be especially relevant to consider epigenetic factors such as life adversities (trauma, disorganized attachment, etc.) as related to its clinical manifestations, rather than genetic factors. Moreover, epigenetics implies overcoming classical dualist dichotomies such as nature-nurture, genotype-phenotype or pathogenesis-pathoplasty. Conclusions: In general, it can be stated that behavior and environment will finally take on a leading role in human development through epigenetic mechanisms.
关键词：epigenetics; gene; behavioral epigenetics; memory; schizophrenia.