文章基本信息

标题：SEXUAL METABOLIC DIFFERENCES IN THE RAT LIMBIC BRAIN
本地全文：下载
作者：Natalia Arias ; Javier Morán ; Nélida Conejo 等
期刊名称：Psicothema
印刷版ISSN：0214-9915
电子版ISSN：1886-144X
出版年度：2013
卷号：25
期号：4
页码：461-467
DOI：10.7334/psicothema2013.100
出版社：Cologio Oficial de Psicólogos del Principado
摘要：Background: There is actually limited evidence about the influence of estrogens on neuronal energy metabolism or functional cerebral asymmetry. In order to evaluate this relationship, eight male and sixteen female adult Wistar rats, divided into estrus and diestrus phase, were used to measure basal neuronal metabolic activity in some of the structures involved in the Papez circuit, using cytochrome c oxidase (C.O.) histochemistry. Method: We used C.O. histochemistry because cytochrome oxidase activity can be considered as a reliable endogenous marker of neuronal activity. Results: We found higher C.O. activity levels in diestrus as compared to estrus and male groups in the prefrontal cortex and thalamus. Conversely, neuronal oxidative metabolism was significantly higher in estrus than in diestrus and male groups in the dorsal and ventral hippocampus (CA1 and CA3) and in the mammillary bodies. However, no hemispheric functional lateralization was found in estrus, diestrus or male groups by C.O. activity. Conclusions: These results suggest a modulatory effect of estrogens on neuronal oxidative metabolism.
关键词：Estrogen; oxidative metabolism; functional cerebral asymmetry; Papez circuit; rat.