文章基本信息

标题：ALTERATIONS OF GRAY AND WHITE MATTER MORPHOLOGY IN OBSESSIVE COMPULSIVE DISORDER
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作者：Oscar F. Gonçalves ; Sonia Sousa ; Sandra Carvalho 等
期刊名称：Psicothema
印刷版ISSN：0214-9915
电子版ISSN：1886-144X
出版年度：2017
卷号：29
期号：1
页码：35-42
DOI：10.7334/psicothema2016.86
出版社：Cologio Oficial de Psicólogos del Principado
摘要：Background: While the ethio-pathogenesis of Obsessive-Compulsive disorder (OCD) remains unknown, there is increased evidence of widespread structural alterations in both white and gray matter in OCD patients that include, but are not restricted, to abnormalities in cortico-striatal-thalamo-cortical (CSTC) regions. The objective of this study was to test the existence of structural alterations in both white and gray matter in a sample of OCD patients when compared with a group of non-clinical matched controls (NCC), using voxel-based morphometry (VBM). Method: Fifteen patients with OCD and 15 NCC underwent MRI structural scanning. Results: Frontal (increased gray matter in the middle frontal gyrus) and subcortical regions (increased white matter in the pallidum) were found to be affected in patients. Additionally, temporal-parietal regions were also found to be affected and highly correlated with OCD symptom severity (decrease of gray matter in the superior parietal lobe and white matter in the angular and superior temporal gyri). Conclusions: These alterations may be associated with prominent OCD symptoms, such as difficulties with inhibitory control (pallidum, angular gyrus), executive functioning (middle frontal gyris), compulsive checking (superior temporal gyrus) and visual-spatial deficits (superior parietal lobe).
关键词：Obsessive-compulsive disorder; gray matter; white matter; voxel based morphometry.