文章基本信息

标题：ASSOCIATIONS BETWEEN EXPERIMENTAL SUBSTANCE USE, FAAH-GENE VARIATIONS, IMPULSIVITY AND SENSATION SEEKING
本地全文：下载
作者：Evelio Huertas ; José A. López-Moreno ; Vanessa Fernández 等
期刊名称：Psicothema
印刷版ISSN：0214-9915
电子版ISSN：1886-144X
出版年度：2019
卷号：31
期号：3
页码：239-245
DOI：10.7334/psicothema2019.27
出版社：Cologio Oficial de Psicólogos del Principado
摘要：Background: Experimental substance use among young people is related to individual factors including personality traits such as impulsivity and sensation seeking, and genetic variations such as single nucleotide polymorphisms (SNPs) in the fatty acid amide hydrolase (FAAH) gene. The objective of this study is to analyze the relationship between these three sets of variables. Methods : Volunteer undergraduate students (N = 861, 76% female, M = 20.7 years) completed an ad hoc questionnaire on variables related to their consumption of alcohol, tobacco, cannabis, synthetic drugs and cocaine. In addition, 591 of them completed the Barratt Impulsiveness Scale-11 (BIS-11) and the Sensation Seeking Scale-V (SSS-V). All participants were genotyped in FAAH C385A SNP and its proxy variant rs12075550. Results : Consistent with previous data, both impulsivity and sensation seeking were associated with most of the variables related to experimental substance use. In addition, we found the first evidence of an association between the rs12075550 SNP and some of these consumption phenotypes. However, no significant association was found between either of the two SNPs and impulsivity or sensation seeking. Conclusions : The results highlight the importance of considering both personality and genetic differences, together with contextual factors, in the analysis of substance use.
关键词：Experimental substance use; impulsivity; sensation seeking; rs12075550; FAAH C385A.