文章基本信息

标题：Physics of compartmentalization: How phase separation and signaling shape membrane and organelle identity
本地全文：下载
作者：Elisa Floris ; Andrea Piras ; Luca Dall’Asta 等
期刊名称：Computational and Structural Biotechnology Journal
印刷版ISSN：2001-0370
出版年度：2021
卷号：19
页码：3225-3233
DOI：10.1016/j.csbj.2021.05.029
出版社：Computational and Structural Biotechnology Journal
摘要：Compartmentalization of cellular functions is at the core of the physiology of eukaryotic cells. Recent evidences indicate that a universal organizing process – phase separation – supports the partitioning of biomolecules in distinct phases from a single homogeneous mixture, a landmark event in both the biogenesis and the maintenance of membrane and non-membrane-bound organelles. In the cell, ‘passive’ (non energy-consuming) mechanisms are flanked by ‘active’ mechanisms of separation into phases of distinct density and stoichiometry, that allow for increased partitioning flexibility and programmability. A convergence of physical and biological approaches is leading to new insights into the inner functioning of this driver of intracellular order, holding promises for future advances in both biological research and biotechnological applications.