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标题：Probiotic and Functional Properties of Limosilactobacillus reuteri INIA P572
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作者：Patricia Diez-Echave ; Izaskun Martín-Cabrejas ; José Garrido-Mesa 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：6
页码：1860
DOI：10.3390/nu13061860
出版社：MDPI Publishing
摘要：Limosilactobacillus reuteri INIA P572 is a strain able to produce the antimicrobial compound reuterin in dairy products, exhibiting a protective effect against some food-borne pathogens. In this study, we investigated some probiotic properties of this strain such as resistance to gastrointestinal passage or to colonic conditions, reuterin production in a colonic environment, and immunomodulatory activity, using different in vitro and in vivo models. The results showed a high resistance of this strain to gastrointestinal conditions, as well as capacity to grow and produce reuterin in a human colonic model. Although the in vitro assays using the RAW 264.7 macrophage cell line did not demonstrate direct immunomodulatory properties, the in vivo assays using a Dextran Sulphate Sodium (DSS)-induced colitic mice model showed clear immunomodulatory and protective effects of this strain.
关键词：Limosilactobacillus reuteri ; probiotic; colonic model; DSS-induced colitic model; immunomodulation; reuterin; protective effect Limosilactobacillus reuteri ; probiotic ; colonic model ; DSS-induced colitic model ; immunomodulation ; reuterin ; protective effect