文章基本信息

标题：Versatile control of the CDC48 segregase by the plant UBX-containing (PUX) proteins
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作者：Junrui Zhang ; Alexandra I. Vancea ; Umar F. Shahul Hameed 等
期刊名称：Computational and Structural Biotechnology Journal
印刷版ISSN：2001-0370
出版年度：2021
卷号：19
页码：3125-3132
DOI：10.1016/j.csbj.2021.05.025
出版社：Computational and Structural Biotechnology Journal
摘要：In plants, AAA-adenosine triphosphatase (ATPase) Cell Division Control Protein 48 (CDC48) uses the force generated through ATP hydrolysis to pull, extract, and unfold ubiquitylated or sumoylated proteins from the membrane, chromatin, or protein complexes. The resulting changes in protein or RNA content are an important means for plants to control protein homeostasis and thereby adapt to shifting environmental conditions. The activity and targeting of CDC48 are controlled by adaptor proteins, of which the plant ubiquitin regulatory X (UBX) domain-containing (PUX) proteins constitute the largest family. Emerging knowledge on the structure and function of PUX proteins highlights that these proteins are versatile factors for plant homeostasis and adaptation that might inspire biotechnological applications.
关键词：CDC48 ; Cofactors ; PUX proteins ; Segregase ; LDAD ; ERAD ; Autophagy ; Structure ; Adaptor