文章基本信息

标题：Macrophage Response Driven by Extracellular ATP
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作者：Jing Wang ; Naoki Takemura ; Tatsuya Saitoh 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2021
卷号：44
期号：5
页码：599-604
DOI：10.1248/bpb.b20-00831
出版社：The Pharmaceutical Society of Japan
摘要：The purine nucleotide ATP is a fundamental unit in cellular energy metabolism. Extracellular ATP and its metabolites are also ligands for a family of receptors, known as purinergic receptors, which are expressed ubiquitously in almost every cell type. In the immune system, extracellular ATP and its signals regulate the migration and activation of immune cells to orchestrate the induction and resolution of inflammation. In this review, we provide an overview of purinergic receptors and their downstream signaling related to macrophage activation. We also discuss the roles of purinergic signaling for macrophage functions in physiological and pathological conditions.
关键词：ATP;cytokine;inflammation;macrophage;purinergic receptor