文章基本信息

标题：Brown Adipose Tissue: New Challenges for Prevention of Childhood Obesity. A Narrative Review
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作者：Elvira Verduci ; Valeria Calcaterra ; Elisabetta Di Profio 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：5
页码：1450
DOI：10.3390/nu13051450
出版社：MDPI Publishing
摘要：Pediatric obesity remains a challenge in modern society. Recently, research has focused on the role of the brown adipose tissue (BAT) as a potential target of intervention. In this review, we revised preclinical and clinical works on factors that may promote BAT or browning of white adipose tissue (WAT) from fetal age to adolescence. Maternal lifestyle, type of breastfeeding and healthy microbiota can affect the thermogenic activity of BAT. Environmental factors such as exposure to cold or physical activity also play a role in promoting and activating BAT. Most of the evidence is preclinical, although in clinic there is some evidence on the role of omega-3 PUFAs (EPA and DHA) supplementation on BAT activation. Clinical studies are needed to dissect the early factors and their modulation to allow proper BAT development and functions and to prevent onset of childhood obesity.
关键词：brown adipose tissue; browning of white adipose tissue; childhood obesity; gut microbiota; breastfeeding; fetal programming; docosahexaenoic acid; eicosapentaenoic acid brown adipose tissue ; browning of white adipose tissue ; childhood obesity ; gut microbiota ; breastfeeding ; fetal programming ; docosahexaenoic acid ; eicosapentaenoic acid