文章基本信息

标题：Diet–Microbiota Interactions in Inflammatory Bowel Disease
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作者：Kohei Sugihara ; Nobuhiko Kamada
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：5
页码：1533
DOI：10.3390/nu13051533
出版社：MDPI Publishing
摘要：Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. Although the precise etiology of IBD is largely unknown, it is widely thought that diet contributes to the development of IBD. Diet shapes the composition of the gut microbiota, which plays critical roles in intestinal homeostasis. In contrast, intestinal inflammation induces gut dysbiosis and may affect the use of dietary nutrients by host cells and the gut microbiota. The interaction of diet and the gut microbiota is perturbed in patients with IBD. Herein, we review the current knowledge of diet and gut microbiota interaction in intestinal homeostasis. We also discuss alterations of diet and gut microbiota interaction that influence the outcome and the nutritional treatment of IBD. Understanding the complex relationships between diet and the gut microbiota provides crucial insight into the pathogenesis of IBD and advances the development of new therapeutic approaches.
关键词：inflammatory bowel disease (IBD); gut microbiota; diet–microbiota interactions; metabolic reprogramming; precision nutrition inflammatory bowel disease (IBD) ; gut microbiota ; diet–microbiota interactions ; metabolic reprogramming ; precision nutrition