文章基本信息

标题：Regulatory Role of Orexin in the Antistress Effect of “Press Tack Needle” Acupuncture Treatment
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作者：Aki Fujiwara ; Mana Tsukada ; Hideshi Ikemoto 等
期刊名称：Healthcare
电子版ISSN：2227-9032
出版年度：2021
卷号：9
期号：5
页码：503
DOI：10.3390/healthcare9050503
出版社：MDPI Publishing
摘要：The aim of this research was to investigate the antistress effect of press tack needle (PTN) acupuncture treatment using rats with social isolation stress (SIS). Rats were divided into non-stress group (Grouped sham), stress group (SIS sham), and PTN-treated SIS group (SIS PTN). Rats in the SIS PTN and SIS sham groups were housed alone for eight days. For the SIS PTN group, a PTN (length, 0.3 or 1.2 mm) was fixed on the GV20 acupoint on day 7. We measured stress behavior based on the time the rats showed aggressive behavior and the levels of plasma corticosterone and orexin A on day 8. In addition, the orexin-1 receptor or orexin-2 receptor antagonist was administered to rats that were exposed to SIS. The duration of aggressive behavior was significantly prolonged in the SIS sham group, and the prolonged duration was inhibited in the SIS PTN (1.2 mm) group. The levels of plasma corticosterone and orexin A were significantly increased in the SIS sham group; however, these increases were inhibited in the SIS PTN group. The aggressive behavior was significantly reduced after the orexin-2 receptor antagonist was administered. These findings suggest that PTN treatment at GV20 may have an antistress effect, and the control of orexin is a mechanism underlying this phenomenon.
关键词：orexin; acupuncture; press tack needle; antistress effect; orexin receptor; aggressive behavior orexin ; acupuncture ; press tack needle ; antistress effect ; orexin receptor ; aggressive behavior