文章基本信息

标题：Periconceptional Folate Supplementation in Women after Bariatric Surgery—A Narrative Review
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作者：An-Katrien Vynckier ; Dries Ceulemans ; Greet Vanheule 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：5
页码：1557
DOI：10.3390/nu13051557
出版社：MDPI Publishing
摘要：The prevalence of obesity is increasing globally, and along with it, there is a growing number of patients opting to undergo bariatric surgery to treat this condition. Whilst it has many advantages, bariatric surgery is known to induce micronutrient deficiency, with possible deleterious effects on overall health. This topic becomes even more relevant during pregnancy, where deficiencies can also affect the developing fetus, possibly being the cause of an increase in congenital anomalies. Most notably amongst these micronutrients is folate, or vitamin B9, which plays an essential role in development, gene expression and genomic stability. As insufficient levels of folate are associated with neural tube defects in the fetus, preventing and treating folate deficiencies during pregnancies after bariatric surgery is a relevant issue. Unfortunately, folate supplementation recommendations for bariatric patients who wish to become pregnant are not clear. In this narrative review, we discuss whether the recommendations for the general population are still valid for bariatric patients. Furthermore, we discuss the role of folate in the human body, folate status in both non-bariatric and bariatric patients, the various types of folate that are available for substitution and the risk associated with over-supplementation.
关键词：bariatric; pregnancy; folate; 5-MTHF; vitamin B9; periconception bariatric ; pregnancy ; folate ; 5-MTHF ; vitamin B9 ; periconception