文章基本信息

标题：Bisacodyl Suppresses TGF-α-Induced MUC5AC Production in NCI-H292 Cells
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作者：Jumpei Ishibashi ; Yoichiro Isohama
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2021
卷号：44
期号：4
页码：590-592
DOI：10.1248/bpb.b20-00886
出版社：The Pharmaceutical Society of Japan
摘要：MUC5AC overproduction is commonly observed in chronic inflammatory lung diseases and worsens these conditions. Therefore, drugs that inhibit MUC5AC production are urgently needed. To identify novel drugs directly inhibiting MUC5AC production, 640 already approved drugs were screened. We found that the laxative bisacodyl suppressed transforming growth factor (TGF)-α-induced MUC5AC production in a concentration-dependent manner. Additionally, bisacodyl also suppressed TGF-α-induced MUC5AC mRNA expression in the same concentration range. These results suggested that bisacodyl could be a new drug for treating mucin overproduction.
关键词：MUC5AC;bisacodyl;mucus production