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标题：Management of hypopituitarism: a perspective from the Brazilian Society of Endocrinology and Metabolism
其他标题：Management of hypopituitarism: a perspective from the Brazilian Society of Endocrinology and Metabolism
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作者：Garmes, Heraldo Mendes ; Boguszewski, César Luiz ; Miranda, Paulo Augusto Carvalho 等
期刊名称：Archives of Endocrinology and Metabolism
印刷版ISSN：2359-3997
出版年度：2021
卷号：65
期号：2
页码：212-230
DOI：10.20945/2359-3997000000335
出版社：Archives of Endocrinology and Metabolism
摘要：Hypopituitarism is a disorder characterized by insufficient secretion of one or more pituitary hormones. New etiologies of hypopituitarism have been recently described, including head trauma, cerebral hemorrhage, and drug-induced hypophysitis. The investigation of patients with these new disorders, in addition to advances in diagnosis and treatment of hypopituitarism, has increased the prevalence of this condition. Pituitary hormone deficiencies can induce significant clinical changes with consequent increased morbidity and mortality rates, while hormone replacement based on current guidelines protects these patients. In this review, we will first discuss the different etiologies of hypopituitarism and then address one by one the clinical aspects, diagnostic evaluation, and therapeutic options for deficiencies of TSH, ACTH, gonadotropin, and GH. Finally, we will detail the hormonal interactions that occur during replacement of pituitary hormones.
关键词：Hypopituitarism; central hypothyroidism; secondary adrenal insufficiency; central hypogonadism and GH deficiency.
其他关键词：Hypopituitarism;central hypothyroidism;secondary adrenal insufficiency;central hypogonadism and GH deficiency