文章基本信息

标题：Development of Personalized Nutrition: Applications in Lactose Intolerance Diagnosis and Management
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作者：Millie Porzi ; Kathryn J. Burton-Pimentel ; Barbara Walther 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：5
页码：1503
DOI：10.3390/nu13051503
出版社：MDPI Publishing
摘要：Recent discoveries in the “omics” field and the growing focus on preventive health have opened new avenues for personalized nutrition (PN), which is becoming an important theme in the strategic plans of organizations that are active in healthcare, food, and nutrition research. PN holds great potential for individual health optimization, disease management, public health interventions, and product innovation. However, there are still multiple challenges to overcome before PN can be truly embraced by the public and healthcare stakeholders. The diagnosis and management of lactose intolerance (LI), a common condition with a strong inter-individual component, is explored as an interesting example for the potential role of these technologies and the challenges of PN. From the development of genetic and metabolomic LI diagnostic tests that can be carried out in the home, to advances in the understanding of LI pathology and individualized treatment optimization, PN in LI care has shown substantial progress. However, there are still many research gaps to address, including the understanding of epigenetic regulation of lactase expression and how lactose is metabolized by the gut microbiota, in order to achieve better LI detection and effective therapeutic interventions to reverse the potential health consequences of LI.
关键词：dairy products; epigenetics; functional foods; genetic testing; gut microbiota; lactase persistence; lactose intolerance; omics; personalized nutrition; polymorphism dairy products ; epigenetics ; functional foods ; genetic testing ; gut microbiota ; lactase persistence ; lactose intolerance ; omics ; personalized nutrition ; polymorphism