文章基本信息

标题：Effect of Physicochemical Properties of Carboxymethyl Cellulose on Diffusion of Glucose
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作者：Elisabeth Miehle ; Stephanie Bader-Mittermaier ; Ute Schweiggert-Weisz 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：5
页码：1398
DOI：10.3390/nu13051398
出版社：MDPI Publishing
摘要：Soluble dietary fibers (SDF) are known to reduce the post-prandial plasma glucose levels. However, the detailed mechanisms of this reduced glucose release in the human gut still remain unclear. The aim of our study was to systematically investigate the effect of different types of SDF on glucose release in an in vitro model as a prerequisite for the selection of fibers suitable for application in humans. Three types of carboxymethyl cellulose (CMC) were used to investigate the correlations between fiber concentration, molecular weight (MW), and viscosity on diffusion of glucose using a side-by-side system. CMC solutions below the coil overlap (c*) influenced the glucose diffusivity only marginally, whereas at concentrations above c* the diffusion of glucose was significantly decreased. Solutions of lower MW exhibited a lower viscosity with lower glucose diffusion compared to solutions with higher MW CMC, attributed to the higher density of the solutions. All CMC solutions showed a systematic positive deviation from Stokes-Einstein behavior indicating a greater rise in viscosity than reduction in diffusion. Therefore, our results pave the way for a new approach for assessing glucose diffusion in solutions comprising dietary fibers and may contribute to further elucidating the mechanisms of post-prandial plasma glucose level reduction.
关键词：in vitro glucose release; sodium carboxymethyl cellulose; soluble dietary fiber; critical concentration; viscosity; diffusion coefficient; molecular weight in vitro glucose release ; sodium carboxymethyl cellulose ; soluble dietary fiber ; critical concentration ; viscosity ; diffusion coefficient ; molecular weight