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标题：A Novel Fluorescent Probe for Selective Detection of Hydrazine and Its Application in Imaging
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作者：Ruo-Jun Man ; Meng-Ke Wu ; Bing Yang 等
期刊名称：Biosensors
电子版ISSN：2079-6374
出版年度：2021
卷号：11
期号：5
页码：130
DOI：10.3390/bios11050130
出版社：MDPI Publishing
摘要：In this work, a novel fluorescent probe with first-time-selected thiazepine backbone, TZPzine-1, was developed for selective detection of hydrazine in water samples and living cells. Chosen from our recent anti-cancer agents, TZPzine-1 inferred structurally based advantages of the optical adjustability and the hydrazine-trapping approach. It also showed applicable properties including high sensitivity (LOD = 50 nM), wide linear range (0–15 equiv.), high selectivity (especially from competing species), rapid response (within 20 min), and practical steadiness in various pH (6.0–11.0) and temperature (15–50 °C) conditions. To satisfy the interdisciplinary requirements in environmental toxicology, TZPzine-1 was successfully applied in water samples and living cells. We hope that the information in this work, as well as the concept of monitoring the nitrogen cycle, may be referable for future research on systematic management.
关键词：hydrazine detection; fluorescent probe; biological imaging; thiazepine moiety; water samples hydrazine detection ; fluorescent probe ; biological imaging ; thiazepine moiety ; water samples