文章基本信息

标题：Stiff Person Syndrome and Gluten Sensitivity
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作者：Marios Hadjivassiliou ; Panagiotis Zis ; David S. Sanders 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：4
页码：1373
DOI：10.3390/nu13041373
出版社：MDPI Publishing
摘要：Stiff person syndrome (SPS) is a rare autoimmune disease characterised by axial stiffness and episodic painful spasms. It is associated with additional autoimmune diseases and cerebellar ataxia. Most patients with SPS have high levels of glutamic acid decarboxylase (GAD) antibodies. The aetiology of SPS remains unclear but autoimmunity is thought to play a major part. We have previously demonstrated overlap between anti-GAD ataxia and gluten sensitivity. We have also demonstrated the beneficial effect of a gluten-free diet (GFD) in patients with anti-GAD ataxia. Here, we describe our experience in the management of 20 patients with SPS. The mean age at symptom onset was 52 years. Additional autoimmune diseases were seen in 15/20. Nineteen of the 20 patients had serological evidence of gluten sensitivity and 6 had coeliac disease. Fourteen of the 15 patients who had brain imaging had evidence of cerebellar involvement. Twelve patients improved on GFD and in seven GFD alone was the only treatment required long term. Twelve patients had immunosuppression but only three remained on such medication. Gluten sensitivity plays an important part in the pathogenesis of SPS and GFD is an effective therapeutic intervention.
关键词：stiff person syndrome; anti-GAD antibodies; gluten sensitivity; coeliac disease; cerebellar ataxia; gluten free diet stiff person syndrome ; anti-GAD antibodies ; gluten sensitivity ; coeliac disease ; cerebellar ataxia ; gluten free diet