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标题：The Effect of Broccoli Sprout Extract on Seasonal Grass Pollen-Induced Allergic Rhinitis
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作者：Joseph Yusin ; Vivian Wang ; Susanne M. Henning 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：4
页码：1337
DOI：10.3390/nu13041337
出版社：MDPI Publishing
摘要：Patients exposed to pollutants are more likely to suffer from allergic rhinitis and may benefit from antioxidant treatment. Our study determined if patients diagnosed with grass-induced allergic rhinitis could benefit from broccoli sprout extract (BSE) supplementation. In total, 47 patients were confirmed with grass-induced allergic rhinitis and randomized to one of four groups: group 1 (nasal steroid spray BSE), group 2 (nasal steroid spray placebo tablet), group 3 (saline nasal spray BSE) and group 4 (saline nasal spray placebo tablet). Peak Nasal Inspiratory Flow (PNIF), Total Nasal Symptoms Scores (TNSS) and nasal mucus cytokine levels were analyzed in samples collected before and after the 3-week intervention. Comparing before and after the intervention, PNIF improved significantly when comparing Groups 1 and 2, vs. placebo, at various time points (p ≤ 0.05 at 5, 15, 60 and 240 min) following nasal challenge, while TNSS was only statistically significant at 5 (p = 0.03), 15 (p = 0.057) and 30 (p = 0.05) minutes. There were no statistically significant differences in various cytokine markers before and after the intervention. Combining nasal corticosteroid with BSE led to the most significant improvement in objective measures.
关键词：glutathione transferase; sulforaphane; broccoli sprout; allergic rhinitis; antioxidant; nasal corticosteroid; peak nasal inspiratory flow; total nasal symptom score; T2 cytokines; allergen extract glutathione transferase ; sulforaphane ; broccoli sprout ; allergic rhinitis ; antioxidant ; nasal corticosteroid ; peak nasal inspiratory flow ; total nasal symptom score ; T2 cytokines ; allergen extract