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标题：High-fructose diet initially promotes increased aortic wall thickness, liver steatosis, and cardiac histopathology deterioration, but does not increase body fat index
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作者：Dian Handayani ; Erlinda Febrianingsih ; Adelya Desi Kurniawati 等
期刊名称：Journal of Public Health Research
印刷版ISSN：2279-9028
电子版ISSN：2279-9036
出版年度：2021
卷号：10
期号：2
页码：1-7
DOI：10.4081/jphr.2021.2181
出版社：PAGEPress Publications
摘要：Background: Dietary fats and fructose have been responsible for inducing obesity and body tissues damage due to the consequence of metabolic syndrome through several mechanisms. The body fat index (BFI) is one of the anthropometric measures used to detect obesity in rats. This study aims to examine the correlation between high-fat high-fructose diet and liver steatosis cell count, early atherosclerosis characteristics, and BFI in Sprague Dawley Rats.Design and methods: This was an experimental design using 2 groups of 12-weeks-old Sprague Dawley (SD) rats. The control group received a standard diet and tap water beverages for 17 weeks. The intervention group was fed with high-fat diet from modified AIN 93-M and additional 30% fructose drink. We analyzed the foam cell count, aortic wall thickness, cardiac histopathology, and liver steatosis cell count after the sacrifice process.Results: The rats in the intervention group had a higher aortic wall thickness, liver steatosis, and foam cell count ( 125%, p0.5; r=0.13).Conclusions: Dietary fat and fructose consumption for 17 weeks promote atherosclerosis, liver steatosis, and cardiac histopathology alteration without increasing BFI.
关键词：Atherosclerosis;body fat index;dietary fructose;liver steatosis;obesity