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标题：The role of the iterative modules in polyketide synthase evolution
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作者：Martin Grininger
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2020
卷号：117
期号：16
页码：8680-8682
DOI：10.1073/pnas.2004190117
出版社：The National Academy of Sciences of the United States of America
摘要：Polyketide synthases (PKSs) assemble activated carboxylic acids to elaborate chemical compounds (1). The key synthetic step is the C-C bond-forming condensation of an acyl moiety (e.g., acetyl-coenzyme A [CoA]) with an α-carboxyacyl moiety (e.g., malonyl-CoA) on release of CO2. The emerging β-ketoacyl compound can optionally be further modified by three accessory catalytic functions. Since this reaction sequence can be repeated, with each elongation varying in accessory catalytic functions, polyketides can be rich in chemistry (Fig. 1 A ). Many polyketides are of pharmaceutical relevance, among them several top-selling small molecule drugs (2): for example, antibiotics (e.g., erythromycin and tetracycline), antineoplastics (e.g., daunorubicin), and immunosuppressants (e.g., rapamycin) (3).