文章基本信息

标题：Reply to Pan et al.: Whole blood metabolome analysis combined with comprehensive frailty assessment
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作者：Masahiro Kameda ; Takayuki Teruya ; Mitsuhiro Yanagida 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2021
卷号：118
期号：1
页码：1
DOI：10.1073/pnas.2016640118
出版社：The National Academy of Sciences of the United States of America
摘要：As frailty patients are vulnerable to stressors, due to declined physiological capacity of organs during aging, comprehensive frailty assessment efficiently predicts health risk of elderlies (1). First, Pan et al. raise concerns about the definition of frailty (2). Currently, there are three major approaches to defining “frailty”: 1) the physical frailty model by Fried Cardiovascular Health Study Index (CHS), 2) the deficit accumulation model covering multimorbidity by Rockwood Frailty Index, and 3) the Edmonton Frailty Scale (EFS) or Tilburg Frailty Indicator, as mixed physical and psychosocial models (3). Thus, EFS is recognized as a valid and reliable measurement tool for the identification of frailty (4) and widely.