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标题：Simplified model assumptions artificially constrain the parameter range in which selection at the holobiont level can occur
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作者：Itay Daybog ; Oren Kolodny
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2020
卷号：117
期号：22
页码：11862-11863
DOI：10.1073/pnas.2004737117
出版社：The National Academy of Sciences of the United States of America
摘要：van Vliet and Doebeli (1) present a multilevel selection framework simulating host–microbiome evolutionary dynamics. The model explores the conditions under which the association between hosts and their “helper” microbiome—microbes that developed a trait that provides a benefit to the host at a cost to themselves—is strong enough to allow for selection at the holobiont level. The model is an important contribution to the holobiont debate, making the notion quantifiable and highlighting the involved parameters. van Vliet and Doebeli conclude that the parameter space in which selection occurs at the holobiont level is extremely restricted (Fig. 1). We show that this result stems from specific model assumptions. Although these assumptions are reasonable as a modeling starting point, slight biologically reasonable modifications lead to qualitatively different outcomes.