文章基本信息

标题：Immunity to commensal skin fungi promotes psoriasiform skin inflammation
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作者：Charlotte Hurabielle ; Verena M. Link ; Nicolas Bouladoux 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2020
卷号：117
期号：28
页码：16465-16474
DOI：10.1073/pnas.2003022117
出版社：The National Academy of Sciences of the United States of America
摘要：Under steady-state conditions, the immune system is poised to sense and respond to the microbiota. As such, immunity to the microbiota, including T cell responses, is expected to precede any inflammatory trigger. How this pool of preformed microbiota-specific T cells contributes to tissue pathologies remains unclear. Here, using an experimental model of psoriasis, we show that recall responses to commensal skin fungi can significantly aggravate tissue inflammation. Enhanced pathology caused by fungi preexposure depends on Th17 responses and neutrophil extracellular traps and recapitulates features of the transcriptional landscape of human lesional psoriatic skin. Together, our results propose that recall responses directed to skin fungi can directly promote skin inflammation and that exploration of tissue inflammation should be assessed in the context of recall responses to the microbiota.
关键词：skin ; psoriasis ; fungi ; microbiota ; Th17