文章基本信息

标题：Translation information processing is regulated by protein kinase C-dependent mechanism in Purkinje cells in murine posterior vermis
本地全文：下载
作者：Rosendo G. Hernández ; Chris I. De Zeeuw ; Ruyan Zhang 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2020
卷号：117
期号：29
页码：17348-17358
DOI：10.1073/pnas.2002177117
出版社：The National Academy of Sciences of the United States of America
摘要：The cerebellar posterior vermis generates an estimation of our motion (translation) and orientation (tilt) in space using cues originating from semicircular canals and otolith organs. Theoretical work has laid out the basic computations necessary for this signal transformation, but details on the cellular loci and mechanisms responsible are lacking. Using a multicomponent modeling approach, we show that canal and otolith information are spatially and temporally matched in mouse posterior vermis Purkinje cells and that Purkinje cell responses combine translation and tilt information. Purkinje cell-specific inhibition of protein kinase C decreased and phase-shifted the translation component of Purkinje cell responses, but did not affect the tilt component. Our findings suggest that translation and tilt signals reach Purkinje cells via separate information pathways and that protein kinase C-dependent mechanisms regulate translation information processing in cerebellar cortex output neurons.
关键词：spatial navigation ; vestibular ; posterior vermis ; Purkinje cell ; cerebellar plasticity