文章基本信息

标题：Functionally distinct Purkinje cell types show temporal precision in encoding locomotion
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作者：Weipang Chang ; Andrea Pedroni ; Victoria Hohendorf 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2020
卷号：117
期号：29
页码：17330-17337
DOI：10.1073/pnas.2005633117
出版社：The National Academy of Sciences of the United States of America
摘要：Purkinje cells, the principal neurons of cerebellar computations, are believed to comprise a uniform neuronal population of cells, each with similar functional properties. Here, we show an undiscovered heterogeneity of adult zebrafish Purkinje cells, revealing the existence of anatomically and functionally distinct cell types. Dual patch-clamp recordings showed that the cerebellar circuit contains all Purkinje cell types that cross-communicate extensively using chemical and electrical synapses. Further activation of spinal central pattern generators (CPGs) revealed unique phase-locked activity from each Purkinje cell type during the locomotor cycle. Thus, we show intricately organized Purkinje cell networks in the adult zebrafish cerebellum that encode the locomotion rhythm differentially, and we suggest that these organizational properties may also apply to other cerebellar functions.
关键词：Purkinje cells ; locomotion ; central pattern generator ; cerebellum ; zebrafish