文章基本信息

标题：Rapid hippocampal plasticity supports motor sequence learning
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作者：Florencia Jacobacci ; Jorge L. Armony ; Abraham Yeffal 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2020
卷号：117
期号：38
页码：23898-23903
DOI：10.1073/pnas.2009576117
出版社：The National Academy of Sciences of the United States of America
摘要：Recent evidence suggests that gains in performance observed while humans learn a novel motor sequence occur during the quiet rest periods interleaved with practice (micro-offline gains, MOGs). This phenomenon is reminiscent of memory replay observed in the hippocampus during spatial learning in rodents. Whether the hippocampus is also involved in the production of MOGs remains currently unknown. Using a multimodal approach in humans, here we show that activity in the hippocampus and the precuneus increases during the quiet rest periods and predicts the level of MOGs before asymptotic performance is achieved. These functional changes were followed by rapid alterations in brain microstructure in the order of minutes, suggesting that the same network that reactivates during the quiet periods of training undergoes structural plasticity. Our work points to the involvement of the hippocampal system in the reactivation of procedural memories.
关键词：hippocampus ; structural plasticity ; functional MRI ; reactivation ; motor sequence learning