文章基本信息

标题：Time cells in the human hippocampus and entorhinal cortex support episodic memory
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作者：Gray Umbach ; Pranish Kantak ; Joshua Jacobs 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2020
卷号：117
期号：45
页码：28463-28474
DOI：10.1073/pnas.2013250117
出版社：The National Academy of Sciences of the United States of America
摘要：The organization of temporal information is critical for the encoding and retrieval of episodic memories. In the rodent hippocampus and entorhinal cortex, evidence accumulated over the last decade suggests that populations of “time cells” in the hippocampus encode temporal information. We identify time cells in humans using intracranial microelectrode recordings obtained from 27 human epilepsy patients who performed an episodic memory task. We show that time cell activity predicts the temporal organization of retrieved memory items. We also uncover evidence of ramping cell activity in humans, which represents a complementary type of temporal information. These findings establish a cellular mechanism for the representation of temporal information in the human brain needed to form episodic memories.
关键词：time cells ; human electrophysiology ; medial temporal lobe ; theta precession