文章基本信息

标题：Involvement of 5‐HT‐BDNF signaling axis in mediating synergistic antidepressant‐like effects after combined administration of two oligosaccharide esters
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作者：Wen Shan Yang ; Zhen‐Guo Shi ; Xian‐Zhe Dong 等
期刊名称：Food Science & Nutrition
电子版ISSN：2048-7177
出版年度：2021
卷号：9
期号：2
页码：1180-1191
DOI：10.1002/fsn3.2098
出版社：John Wiley & Sons, Ltd.
摘要：Potential mechanisms of depression involving herbal medicines and their specific compounds include elevated 5‐HT level and downstream BDNF pathway. To identify potentially new combined therapeutic strategies, 3,6'‐disinapoylsucrose (DISS) and tenuifoliside A (TFSA) have been observed to show antidepressant‐like effects and its related 5‐HT‐BDNF pathway. We have tried to investigate whether combined administration of DISS and TFSA exerted more effective in the treatment of depression, as assessed through tail suspension test (TST) and forced swimming test (FST). In addition, we also analyzed the expression of three important proteins, cyclic adenosine monophosphate (cAMP) response element binding (CREB), brain‐derived neurotrophic factor (BDNF), and cAMP‐regulated transcriptional coactivators (CRTC1), which have been shown to be involved in the regulation of the neurotrophic factors in the hippocampus. The DISS and TFSA separately, both at a dose of 5 mg/kg each, displayed small effect in the immobility time. However, combined treatment of these two in multiple doses exhibited better effect. Moreover, combined treatment of DISS and TFSA also demonstrated enhanced levels of 5‐hydroxytryptamine (5‐HT), and stronger increase in the phosphorylation levels of CREB, BDNF, and CRTC1 proteins in the hippocampus. Overall, our results indicated that coadministration of these two oligosaccharide esters at low dose may induce more pronounced antidepressant activity, in comparison with individual treatment even at high dosage. Thus, the antidepressant properties of both these compounds can be attributed to their ability to influence 5‐HT and BDNF pathway, and thereby suggesting that this combination strategy can definitely act as alternative therapy for depression disorder with very limited side effects.
关键词：BDNF;herb activity compounds;multi‐target;synergistic mechanism