文章基本信息

标题：Leishmaniasis: effect of enalaprilat on the production of (ON) and cytokines in vitro
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作者：Cristiane Ferreira Lopes de Araújo ; Josué Ribeiro da Silva Nunes ; Rogério Alexandre Nunes dos Santos 等
期刊名称：Research, Society and Development
电子版ISSN：2525-3409
出版年度：2021
卷号：10
期号：3
页码：1-10
DOI：10.33448/rsd-v10i3.12949
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：Leishmaniasis is neglected diseases; the drugs used have significant toxic effects that compromise patient compliance, and increased loss of efficacy due to increased resistant infectious strains. Assays on Swiss mice infected with Leishmania brasiliensis and treated with Angiotensin-Suppressing Enzyme (ACE) inhibitors showed that, in addition to the classical effects on the cardiovascular system, some of these inhibitors had effects on nonhemodynamic, immunomediated functions such as cytokine production. In this study, the effect of enalaprilate on nitric oxide (NO) production and cytokines were evaluated, i.e., interleukins-10 and 12 and IFN-γ in J774 A.1 macrophages infected by Leishmania braziliensis. Enalaprilate demonstrated in vitro immunomodulatory capacity, increasing the release of NO to induce IL-12 and IFN-γ also decreasing il-10 release.